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Polyethylene terephthalate (PET)

Polyethylenterepthalate

Polyethylene terephthalate (CHEBI:131701) is a synthetic polymer of repeating units of terephthalic acid (CHEBI:30043) and ethylene glycol (CHEBI:30742). PET is mainly used for the production of PET bottles, foil and various fibers in textile industry. PET is one of the few polymers, for which a number of microbial enzymes are known. They belong to the cutinases (EC 3.1.1.74), lipases (EC 3.1.1.3) and carboxylesterases (EC 3.1.1.1 /EC 3.1.1.101/ EC 3.1.1.2) and can act on amorphous but not crystalline PET. These enzymes break the ester bond in the polymer to either produce bis (2-hydroxyethyl) terephthalate (BHET), mono (2-hydroxyethyl) terephthalate (MHET) or terephthalic acid (TPA) and ethylene glycol (EG). The enzymes act as exo-enzymes. MHET can subsequently be cleaved with a specific MHETase (EC 3.1.1.102) and the TPA monomers degraded via cleavage of the aromatic ring structure using known aryl pathways (Wei et al., 2017; Danso et al., 2019, Taniguchi et al., 2019). PET-active enzymes are often designated 'PETases'. Notably, the majority of all PET-active enzmes are promiscous enzymes.

Currently known and biochemically characterized active PET hydrolases are listed below and grouped according to their phylogenetic affiliation. Predicted and not characterized enzymes are not included. For multiple PDB entries only one lead struture is included.

In case you are aware of PET-active biochemically characterized enzymes that are not listed below, please contact the PAZY team.

Cite: Buchholz, P.C.F., Feuerriegel, G., Zhang, H., Perez-Garcia, P., Nover, L.-L., Chow, J., Streit, W.R. and Pleiss, J (2022);
Plastics degradation by hydrolytic enzymes: The Plastics-Active Enzymes Database - PAZy
(download link for reference manager)

Microbial host/enzyme/geneEC numberReferenceGenBank/ UniProt/MGnifyPDB entryNCBI BLAST
Bacteria
Pseudomonadota (synonym with Proteobacteria)
Ideonella sakaiensis 201-F61 , ISPETase, ISF6_4831
(→DuraPETase) (→ThermoPETase) (→Fast-PETase) (→HotPETase) (→DepoPETase)		EC 3.1.1.101Yoshida, 2016; Han 2017; Cui, 2021; Son, 2019; Lu, 2022; Bell, 2022; Shi et al., 2023; Sevilla et al., 2023A0A0K8P6T75XFY, and othersWP_054022242.1
Oleispira antarctica RB-8, PET5, LipA (=Oacut) EC 3.1.1.1Danso, 2018, Blasquez-Sanchez, 2021R4YKL9_OLEAN MBQ0729274.1
Vibrio gazogenes, PET6, BSQ33_03270 EC 3.1.1.1Danso, 2018A0A1Z2SIQ1_VIBGA7Z6BASA57064.1
Caldimonas brevitalea, PET12 (PbCut;SbCut), AAW51_2473 EC 3.1.1.1Danso, 2018; Chen, 2021; Avilan,2023A0A0G3BI90_9BURK AKJ29164.1
Marinobacter sp., PLE628 EC 3.1.1.1Meyer Cifuentes, 2022OK5588257VMDOK558825.1
Marinobacter sp., PLE629 EC 3.1.1.1Meyer Cifuentes, 2022OK5588247VPAOK558824.1
Pseudomonas oleovorans/ pseudoalcaligenes DSM 50188,
PpCutA/PoCut		EC 3.1.1.74Inglis, 2011; Haernvall, 2017ADK73612 ADK73612
Pseudomonas pelagia DSM 25163, PpelaLip EC 3.1.1.74Haernvall, 2017 KU695573 ANP21910.1
Halopseudomonas aestusnigri VGXO14, PE-H, B7O88_11480 EC 3.1.1.1Bollinger, 2020A0A1H6AD456SBN, and othersWP_088276085.1
Pseudomonas mendocina ATCC 53552, PmC EC 3.1.1.3Ronkvist, 2009N20M5AZM0162FX52FX5_A
Pseudomonas saudimassiliensis, PsCut EC 3.1.1.1Avilan, 2023A0A078MGG88AISWP_044499735.1
Halopseudomonas bauzanensis, PbauzCut EC 3.1.1.1Avilan, 2023A0A031MKR88AITWP_036989706.1
Pseudomonas alcaligenes, PaCut EC 3.1.1.1Avilan, 2023SUD16364.1 SUD16364.1
Moraxella sp.TA144, lip1, Mors1 EC 3.1.1.3Blasquez-Sanchez, 2021P198338SPKP19833.1
Pseudomonas pseudoalcaligenes, PpEst (tesA) EC 3.1.1.2Haernvall, 2017, Wallace, 2016W6R2Y2 WP_003460012.1
Pseudomonas sp., esterase MG8 EC 3.1.1.1Eiamthong, 2022MGYP000532440779 MGYP000532440779
Pseudomonas sp. strain 9.2, EstB EC 3.1.1.1Edwards et al., 2022WP_085690612 WP_085690612
Rhizobacter gummiphilus NS21, RgPETase/RgCut-I EC 3.1.1.1Sagong, 2021, Avilan, 2023A4W93_059507DZT, and othersA4W93_05950
Rhizobacter gummiphilus, RgCut-II EC 3.1.1.1Avilan, 2023WP_085749238.18AIRWP_085749238.1
Ketobacter sp., Enzyme 403 Erickson, 2022RLU00646.1 RLU00646.1
Ketobacter sp., Enzyme 409 Erickson, 2022RLT92980.1 RLT92980.1
Ketobacter alkanivorans, Enzyme 412 Erickson, 2022WP_101893509.1 WP_101893509.1
Comamonadaceae bacterium, Enzyme 406 Erickson, 2022ODU60407.1 ODU60407.1
Caldimonas taiwanensis+D57, CtPL (Enzyme 504) Chen, 2021; Erickson, 2022WP_062195544.1 WP_062195544.1
Acidovorax delafieldii, PbsA/AdCut EC 3.1.1.1Avilan, 2023Q8RR62 BAB86909.1
Aquabacterium parvum, ApLip-Ec Ho, 2023
Burkholderia bacterium, BurPL Chen, 2021; Chen, 2021;Sagong, 2022; Huang, 2023A0A1F4JXW87CWGOGB27210
Pseudomonas sp., GlacPETase Qi, 2023
Halopseudomonas formosensis, Hfor_PE-H de Witt, 2023WP_090538641.1 WP_090538641.1
Pseudomonas sp. JM16B3, jmPE13 Zhou, 2024
Pseudomonas sp. JM16B3, jmPE14 Zhou, 2024
Pseudomonadota bacterium, dsPETase05 Chen, 2024
Pseudomonadota bacterium, dsPETase06 Chen, 2024MEC8523093.1 MEC8523093.1
Brucella, PD3 Jin, 2024QPA27412 QPA27412
Pseudomonas paralcaligenes MRCP1333, PpPETase Han, 2024WP_220815207 WP_220815207
Rhizobacter sp., APET-17 Wu et al., 2025MBX3625601.1 MBX3625601.1
Alphaproteobacteria bacterium, APET-23 Wu et al., 2025MSQ87502.1 MSQ87502.1
Halopseudomonas oceani, APET-27 Wu et al., 2025WP_104739856.1 WP_104739856.1
Cellvibrionaceae bacterium, APET-28 Wu et al., 2025MBX2857432.1 MBX2857432.1
Gammaproteobacteria bacterium, APET-29 Wu et al., 2025MBE65357.1 MBE65357.1
Oleibacter sp. HI0075, APET-32 Wu et al., 2025KZY99137.1 KZY99137.1
Steroidobacter cummioxidans, 247 Seo et al., 2025WP_116813002.1 WP_116813002.1
Pseudomonadales bacterium, PC8 Hong et al., 2023MBA55398.1 MBA55398.1
Rhizobacter sp., DP038 Norton-Baker et al., 2025MBX3624429.1 MBX3624429.1
Piscinibacter gummiphilus, DP039 Norton-Baker et al., 2025WP_085750434.1 WP_085750434.1
Pseudomonas fluvialis, DP078 Norton-Baker et al., 2025WP_184682765.1 WP_184682765.1
Rhizobacter sp., ESM045 Norton-Baker et al., 2025MBX3621832.1 MBX3621832.1
Pseudomonas subflava, ESM096 Norton-Baker et al., 2025WP_252275389.1 WP_252275389.1
Rhizobacter sp., ESM169 Norton-Baker et al., 2025MBT9528079.1 MBT9528079.1
Halopseudomonas yangmingensis, ESM186 Norton-Baker et al., 2025WP_093473685.1 WP_093473685.1
Actinomycetota
LCC, leaf compost metagenome, highly similar to HRB29 locus GBD22443EC 3.1.1.74Sulaiman, 2012; Shirke, 2018; Tournier, 2020G9BY574EBO and othersG9BY57.1
BhrPETase from HR29 bacterium, >96% identical to LCCEC 3.1.1.74Xi, 2021GBD224437EOAGBD22443.1
Thermobifida (Thermomonspora) fusca
T. fusca DSM43793, BTA-1, TfHEC 3.1.1.74Dresler, 2006; Müller 2005; Kleeberg 1998; 2005Q6A0I45ZOAQ6A0I4
T. fusca DSM43793, BTA-2, TfHEC 3.1.1.74Dresler, 2006; Müller 2005; Kleeberg 1998; 2005AJ810119 Q6A0I3
T. fusca DSM44342, TfH42_Cut1EC 3.1.1.74Herrero Acero, 2011 E9LVI0_THEFU ADV92528.1
T. fusca (strain YX), WSH03-11, Tfu_0883EC 3.1.1.74Chen, 2008; Su, 2013; Lykidis, 2007 Q47RJ6_THEFY Q47RJ6
T. fusca (strain YX), WSH03-11, Tfu_0882EC 3.1.1.74Chen, 2008 Q47RJ7_THEFY Q47RJ7
T. fusca, TfCut_1 (Cut-1.kw3) (only active on 3PET; not on higher polymers!)3.1.1.101Herrero Acero, 2011E5BBQ2 E5BBQ2
T. fusca, TfCut_2 (Cut-2.kw3)EC 3.1.1.74Furukawa, 2019, Roth, 2014; Wei 2016E5BBQ3_THEFU4CG1CBY05530
T. fusca NRRL B-8184, Cut1EC 3.1.1.74Hedge, 2013JN129499.1 AET05798.1
T. fusca NRRL B-8184, Cut2EC 3.1.1.74Hedge, 2013JN129500.1 AET05799.1
T. fusca, Enzyme 701 Erickson, 2022WP_104613137.1 WP_104613137.1
T. fusca, Enzyme 702 Erickson, 2022ADM47605.17QJQADM47605.1
T. cellulosilytica DSM44535, Thc_Cut1EC 3.1.1.74Herrero Acero, 2011, Ribitsch 2017ADV92526.15LUIADV92526.1
T. cellulosilytica DSM44535, Thc_Cut2EC 3.1.1.74Herrero Acero, 2011 Ribitsch 2017ADV925715LUJADV92527.1
T. cellulosilytica, Enzyme 711 Erickson, 2022WP_083947829.17QJTWP_083947829.1
T. curvata DSM43183, Tcur_1278EC 3.1.1.74Wei, 2014D1A9G5 ACY96861.1
T. curvata DSM43183, Tcur0390EC 3.1.1.74Wei, 2014ACY95991.1 ACY95991.1
T. halotolerans, Thh_EstEC 3.1.1.1Ribitsch, 2012H6WX58 AFA45122.1
T. alba (AHK119), Est1 (Hydrolase 4); Enzyme 708EC 3.1.1.1Hu, 2010; Erickson, 2022BAI99230 BAI99230.2
T. alba DSM43185, Tha_Cut1, cut1 EC 3.1.1.74Ribitsch, 2012E9LVH7 ADV92525.1
T. alba AHK119, Est119, est2EC 3.1.1.1Kitadokoro, 2019F7IX06 6AIDBAK48590.1
Saccharomonospora (Thermoactinomyces) viridis AHK190, Cut190EC 3.1.1.74Miyakawa, 2014; Kawai, 2014; Oda, 2018W0TJ644WFK and othersBAO42836.1
Actinobacteria bacterium OK074, Enzyme 405 Erickson, 2022WP_082414832.1 WP_082414832.1
Allorhizocoloa rhizosphaerae, Enzyme 407 Erickson, 2022WP_117215036.1 WP_117215036.1
Nocardioidaceae bacterium, Enzyme 503 Erickson, 2022EGD44994.1 EGD44994.1
Marinactinospora thermotolerans, MtCut / Enzyme 606 Liu et al. 2022 Erickson, 2022,WP_078759821.17QJOWP_078759821.1
Actinobacteria bacterium OV320, Enzyme 607 Erickson, 2022WP_107095481.1 WP_107095481.1
Saccharopolyspora flava, Enzyme 611 Erickson, 2022WP_093412886.17QJPWP_093412886.1
Rhodococcus sp., Rcut (PBATh), OL660765 Won, 2022UNZ22463.1 UNZ22463.1
Streptomyces scabiei, Sub1 Jabloune, 2020QEX94755.1 QEX94755.1
Streptomyces sp. SM14, SM14est Almeida, 2019; Carr, 2023DAC80635 DAC80635
Compost metagenome, PHL-12 Sonnendecker, 2022SAY37579.1 SAY37579.1
Compost metagenome, PHL-22 Sonnendecker, 2022SAY37582.1 SAY37582.1
Amycolatopsis bacterium, PET40 Zhang, 2023WAU86704.18A2CWAU86704.1
Microbispora sp., SIBER-1 Tiong, 2023WOR09923 WOR09923
Aeromicrobium, dsPETase01 Chen, 2024
Dietzia kunjamensis, Dkca1 Singh, 2024WID88783.1 WID88783.1
Streptomyces calvus DSM 41452, ScPETase Han, 2024QDI72884 QDI72884
Kibdelosporangium aridum, KaPETase Cavus, 2025A0A1W2FU08 WP_143447025.1
Lentzea guizhouensis, APET-5 Wu et al., 2025WP_218920366.1 WP_218920366.1
Kibdelosporangium banguiense, KbPETase Wu et al., 2025WP_209642273.1 WP_209642273.1
Actinomadura atramentaria, APET-15 Wu et al., 2025WP_019629726.1 WP_019629726.1
Thermomonospora umbrina, APET-19 Wu et al., 2025WP_116023875.1 WP_116023875.1
Solirubrobacteraceae bacterium, APET-20 Wu et al., 2025MBO9532528.1 MBO9532528.1
Actinomadura flavalba, APET-24 Wu et al., 2025WP_018657411.1 WP_018657411.1
Actinophytocola sp., APET-25 Wu et al., 2025MPZ00478.1 MPZ00478.1
Dactylosporangium siamense, APET-26 Wu et al., 2025WP_203847453.1 WP_203847453.1
Micromonospora pattaloongensis, Mipa-P Seo et al., 2025SDZ16714.1 SDZ16714.1
Micromonospora pattaloongensis, 1628 Seo et al., 2025WP_091553551.1 WP_091553551.1
Micromonospora ureilytica, 1611 Seo et al., 2025WP_124822775.1 WP_124822775.1
Plantactinospora sp. CNZ320, 1625 Seo et al., 2025WP_101366623.1 WP_101366623.1
Micromonospora arborensis, 1603 Seo et al., 2025WP_110567505.1 WP_110567505.1
Kibdelosporangium aridum, 1663 Seo et al., 2025WP_084434874.1 WP_084434874.1
Kutzneria buriramensis, Kubu-P Seo et al., 2025WP_116180173.1 WP_116180173.1
Plantactinospora sp. B6F1, 1538 Seo et al., 2025WP_130464304.1 WP_130464304.1
Saccharothrix sp. CB00851, 1465 Seo et al., 2025WP_073887759.1 WP_073887759.1
Micromonospora chokoriensis, 1621 Seo et al., 2025WP_088988822.1 WP_088988822.1
Micromonospora lupini str. Lupac 08, 1617 Seo et al., 2025CCH19814.1 CCH19814.1
Micromonospora sp. NRRL B-16802, 1534 Seo et al., 2025WP_082377728.1 WP_082377728.1
Micromonospora sp. KC723, 1489 Seo et al., 2025WP_132386942.1 WP_132386942.1
Micromonospora sp. KC213, 1521 Seo et al., 2025WP_132337032.1 WP_132337032.1
Verrucosispora sp. CNZ293, 1525 Seo et al., 2025WP_099848711.1 WP_099848711.1
Kribbella albertanoniae, 1468 Seo et al., 2025WP_132413760.1 WP_132413760.1
Catellatospora sichuanensis, 1507 Seo et al., 2025WP_144126986.1 WP_144126986.1
Saccharothrix sp. NRRL B-16348, 1491 Seo et al., 2025WP_082403176.1 WP_082403176.1
Streptomyces violaceusniger, 1821 Seo et al., 2025WP_137976057.1 WP_137976057.1
Streptomyces sp. RP5T, 1477 Seo et al., 2025WP_125191182.1 WP_125191182.1
Saccharothrix saharensis, 1482 Seo et al., 2025WP_141984372.1 WP_141984372.1
Catellatospora paridis, 1522 Seo et al., 2025WP_155388305.1 WP_155388305.1
Micromonospora, 1546 Seo et al., 2025WP_013736455.1 WP_013736455.1
Thermoactinospora rubra, 385 Seo et al., 2025WP_143590710.1 WP_143590710.1
Micromonospora orduensis, 1642 Seo et al., 2025WP_139584963.1 WP_139584963.1
Actinomadura, 917 Seo et al., 2025WP_083950838.1 WP_083950838.1
Streptomyces sp. CB00455, 1537 Seo et al., 2025OKK16161.1 OKK16161.1
Verrucosispora sp. SN26_14.1, 1519 Seo et al., 2025WP_131056699.1 WP_131056699.1
Lentzea aerocolonigenes, 1678 Seo et al., 2025WP_045318561.1 WP_045318561.1
Streptomyces acidiscabies, 1496 Seo et al., 2025WP_075737041.1 WP_075737041.1
Lentzea guizhouensis, 1169 Seo et al., 2025WP_065917710.1 WP_065917710.1
Micromonospora violae, 1637 Seo et al., 2025WP_130401777.1 WP_130401777.1
Dactylosporangium aurantiacum, 1463 Seo et al., 2025WP_081971423.1 WP_081971423.1
Micromonospora sediminimaris, 1545 Seo et al., 2025WP_093411427.1 WP_093411427.1
Amycolatopsis kentuckyensis, 554 Seo et al., 2025WP_086849962.1 WP_086849962.1
Lentzea atacamensis, 1573 Seo et al., 2025WP_109639600.1 WP_109639600.1
Crossiella equi, 1654 Seo et al., 2025WP_086784246.1 WP_086784246.1
Streptomyces achromogenes, 1555 Seo et al., 2025WP_078844206.1 WP_078844206.1
Micromonospora haikouensis, 1591 Seo et al., 2025WP_091283529.1 WP_091283529.1
Micromonospora saelicesensis, 1620 Seo et al., 2025WP_112669767.1 WP_112669767.1
Luteipulveratus halotolerans, 1240 Seo et al., 2025KNX38636.1 KNX38636.1
Micromonospora carbonacea, 1594 Seo et al., 2025WP_083302694.1 WP_083302694.1
Amycolatopsis vastitatis, 1457 Seo et al., 2025WP_093954453.1 WP_093954453.1
Micromonospora coriariae, 1641 Seo et al., 2025WP_089021493.1 WP_089021493.1
Nocardioides albertanoniae, 1309 Seo et al., 2025TQL66274.1 TQL66274.1
Amycolatopsis, 414 Seo et al., 2025WP_123685830.1 WP_123685830.1
Lentzea albidocapillata, 1506 Seo et al., 2025WP_084400763.1 WP_084400763.1
Micromonospora sp. KC606, 1493 Seo et al., 2025WP_132183354.1 WP_132183354.1
Herbihabitans rhizosphaerae, 1395 Seo et al., 2025RZS34008.1 RZS34008.1
Streptomyces ipomoeae, 1478 Seo et al., 2025WP_141569747.1 WP_141569747.1
Micromonospora inaquosa, 1571 Seo et al., 2025WP_124770494.1 WP_124770494.1
Microbispora sp. GKU 823, 169 Seo et al., 2025OPG10926.1 OPG10926.1
Actinoplanes subtropicus, 1638 Seo et al., 2025WP_051808300.1 WP_051808300.1
Microbispora triticiradicis, 1868 Seo et al., 2025WP_111700265.1 WP_111700265.1
Kutzneria sp. 744, 1718 Seo et al., 2025WP_084578793.1 WP_084578793.1
Micromonospora chalcea, 401 Seo et al., 2025WP_104115406.1 WP_104115406.1
Streptomyces sp. MA5143a, 1392 Seo et al., 2025SPF04022.1 SPF04022.1
Micromonospora globbae, 486 Seo et al., 2025WP_120326365.1 WP_120326365.1
Actinokineospora spheciospongiae, 1424 Seo et al., 2025WP_110080872.1 WP_110080872.1
Lentzea kentuckyensis, 1475 Seo et al., 2025WP_086668955.1 WP_086668955.1
Amycolatopsis arida, 282 Seo et al., 2025WP_092528534.1 WP_092528534.1
Micromonospora sp. HM134, 1635 Seo et al., 2025WP_145923095.1 WP_145923095.1
Actinokineospora iranica, 1228 Seo et al., 2025WP_091450391.1 WP_091450391.1
Streptomyces dysideae, 1876 Seo et al., 2025WP_067035690.1 WP_067035690.1
Actinomadura rubteroloni, 1340 Seo et al., 2025WP_103564314.1 WP_103564314.1
Streptomyces sp. SCA2-2, 191 Seo et al., 2025WP_129849678.1 WP_129849678.1
Thermomonospora echinospora, PC3 Hong et al., 2023WP_103939557.1 WP_103939557.1
Amycolatopsis eburnea, PC4 Hong et al., 2023WP_125313231.1 WP_125313231.1
Actinokineospora bangkokensis, PC5 Hong et al., 2023WP_075975245.1 WP_075975245.1
Thermobifida cellulosilytica, PC6 Hong et al., 2023WP_068752972.1 WP_068752972.1
Jonesia denitrificans DSM 20603, DP003 Norton-Baker et al., 2025ACV09511 ACV09511
Actinokineospora alba, DP006 Norton-Baker et al., 2025TDP67440 TDP67440
Actinokineospora spheciospongiae, DP007 Norton-Baker et al., 2025WP_035284691 WP_035284691
Herbihabitans rhizosphaerae, DP008 Norton-Baker et al., 2025WP_130342639 WP_130342639
Actinomadura physcomitrii, DP016 Norton-Baker et al., 2025WP_151597653.1 WP_151597653.1
Actinokineospora xionganensis, DP017 Norton-Baker et al., 2025WP_187224800.1 WP_187224800.1
Dactylosporangium sp., DP021 Norton-Baker et al., 2025MBT8227529.1 MBT8227529.1
Actinokineospora spheciospongiae, DP040 Norton-Baker et al., 2025WP_233427406.1 WP_233427406.1
Actinoplanes sp. DH11, DP043 Norton-Baker et al., 2025WP_229068674.1 WP_229068674.1
Actinomadura rayongensis, DP054 Norton-Baker et al., 2025WP_161104454.1 WP_161104454.1
Actinomycetes bacterium, DP056 Norton-Baker et al., 2025MGYP001489421514 MGYP001489421514
Acidimicrobiales bacterium, DP057 Norton-Baker et al., 2025MBN2622270.1 MBN2622270.1
Micromonosporales bacterium, DP059 Norton-Baker et al., 2025MGYP001121581011 MGYP001121581011
Paractinoplanes polyasparticus, DP061 Norton-Baker et al., 2025WP_221382552.1 WP_221382552.1
Micromonosporales bacterium, DP068 Norton-Baker et al., 2025MGYP000271253724 MGYP000271253724
Thermoleophilaceae bacterium, DP080 Norton-Baker et al., 2025MBJ7347705.1 MBJ7347705.1
Micromonosporales bacterium, DP081 Norton-Baker et al., 2025MGYP000221121644 MGYP000221121644
Paractinoplanes durhamensis, DP082 Norton-Baker et al., 2025WP_203733135.1 WP_203733135.1
Hamadaea sp., DP084 Norton-Baker et al., 2025NUT34383.1 NUT34383.1
Promicromonospora panici, DP089 Norton-Baker et al., 2025WP_129786244.1 WP_129786244.1
Streptomyces sp. ST2-7A, DP090 Norton-Baker et al., 2025WP_233872418.1 WP_233872418.1
Microbispora catharanthi, DP092 Norton-Baker et al., 2025WP_139580723.1 WP_139580723.1
Saccharothrix sp. S26, ESM006 Norton-Baker et al., 2025WP_267938240.1 WP_267938240.1
Microbispora, ESM010 Norton-Baker et al., 2025WP_167521412.1 WP_167521412.1
Solwaraspora sp. WMMA2059, ESM012 Norton-Baker et al., 2025WBC00352.1 WBC00352.1
Microbispora oryzae, ESM021 Norton-Baker et al., 2025WP_210157342.1 WP_210157342.1
Microbispora triticiradicis, ESM024 Norton-Baker et al., 2025MBO4274871.1 MBO4274871.1
Microbispora sp. ATCC PTA-5024, ESM026 Norton-Baker et al., 2025WP_232326807.1 WP_232326807.1
Phytohabitans rumicis, ESM033 Norton-Baker et al., 2025GFJ87714.1 GFJ87714.1
Saccharothrix deserti, ESM035 Norton-Baker et al., 2025WP_158852571.1 WP_158852571.1
Microbispora sp. H10830, ESM038 Norton-Baker et al., 2025WP_182904095.1 WP_182904095.1
Streptomyces sp. NRRL F-5123, ESM043 Norton-Baker et al., 2025WP_031525917.1 WP_031525917.1
Acidimicrobiales bacterium, ESM050 Norton-Baker et al., 2025GIU85367.1 GIU85367.1
Paractinoplanes deccanensis, ESM052 Norton-Baker et al., 2025WP_203777396.1 WP_203777396.1
Phytohabitans houttuyneae, ESM058 Norton-Baker et al., 2025WP_173061649.1 WP_173061649.1
Micromonospora craterilacus, ESM059 Norton-Baker et al., 2025WP_111214096.1 WP_111214096.1
Paractinoplanes rishiriensis, ESM060 Norton-Baker et al., 2025WP_203790592.1 WP_203790592.1
Plantactinospora alkalitolerans, ESM061 Norton-Baker et al., 2025MBF9135495.1 MBF9135495.1
Micromonospora taraxaci, ESM062 Norton-Baker et al., 2025TWG17167.1 TWG17167.1
Phytohabitans aurantiacus, ESM064 Norton-Baker et al., 2025GLI01021.1 GLI01021.1
Micromonospora qiuiae, ESM065 Norton-Baker et al., 2025WP_204038550.1 WP_204038550.1
Micromonospora saelicesensis, ESM069 Norton-Baker et al., 2025WP_181548579.1 WP_181548579.1
Micromonospora sp. AKA109, ESM070 Norton-Baker et al., 2025GHJ08786.1 GHJ08786.1
Micromonospora rifamycinica, ESM080 Norton-Baker et al., 2025WP_084261341.1 WP_084261341.1
Micromonospora sp. CPCC 205371, ESM081 Norton-Baker et al., 2025WP_265247586.1 WP_265247586.1
Dactylosporangium vinaceum, ESM082 Norton-Baker et al., 2025UAC02078.1 UAC02078.1
Actinoallomurus spadix, ESM084 Norton-Baker et al., 2025WP_252811421.1 WP_252811421.1
Dactylosporangium sucinum, ESM090 Norton-Baker et al., 2025WP_229836555.1 WP_229836555.1
Dactylosporangium siamense, ESM093 Norton-Baker et al., 2025WP_239135698.1 WP_239135698.1
Dactylosporangium matsuzakiense, ESM097 Norton-Baker et al., 2025WP_271190254.1 WP_271190254.1
Micromonospora sp. RL09-050-HVF-A, ESM101 Norton-Baker et al., 2025MBW4703769.1 MBW4703769.1
Micromonospora sp. D93, ESM121 Norton-Baker et al., 2025WP_247684544.1 WP_247684544.1
Verrucosispora sp. WMMA2121, ESM128 Norton-Baker et al., 2025WP_269740835.1 WP_269740835.1
Micromonospora sp. MH99, ESM130 Norton-Baker et al., 2025MCF0091346.1 MCF0091346.1
Actinoplanes ianthinogenes, ESM136 Norton-Baker et al., 2025GGR16917.1 GGR16917.1
Amycolatopsis sp. CA-128772, ESM139 Norton-Baker et al., 2025WP_199199185.1 WP_199199185.1
Amycolatopsis sp. WQ 127309, ESM140 Norton-Baker et al., 2025WP_247056560.1 WP_247056560.1
Catellatospora bangladeshensis, ESM144 Norton-Baker et al., 2025WP_239125827.1 WP_239125827.1
Paractinoplanes tereljensis, ESM156 Norton-Baker et al., 2025WP_203812622.1 WP_203812622.1
Micromonospora acroterricola, ESM157 Norton-Baker et al., 2025PWR09075.1 PWR09075.1
Rhizocola hellebori, ESM159 Norton-Baker et al., 2025WP_203906211.1 WP_203906211.1
Asanoa hainanensis, ESM160 Norton-Baker et al., 2025WP_144022925.1 WP_144022925.1
Amycolatopsis tolypomycina, ESM167 Norton-Baker et al., 2025WP_091317053.1 WP_091317053.1
Micromonospora sp. CP22, ESM173 Norton-Baker et al., 2025MTK05241.1 MTK05241.1
Catellatospora methionotrophica, ESM177 Norton-Baker et al., 2025WP_239086781.1 WP_239086781.1
Verrucosispora sioxanthis, TEP010 Norton-Baker et al., 2025WP_164449727.1 WP_164449727.1
Thermobifida cellulosilytica, TEP014 Norton-Baker et al., 2025MGYP001477358452 MGYP001477358452
Streptomyces sp. A012304, TEP024 Norton-Baker et al., 2025WP_264933993.1 WP_264933993.1
Actinomycetes bacterium, TEP037 Norton-Baker et al., 2025MGYP000321434903 MGYP000321434903
Crossiella sp. SN42, TEP041 Norton-Baker et al., 2025WP_256510026.1 WP_256510026.1
Dactylosporangium aurantiacum, TEP054 Norton-Baker et al., 2025WP_260709492.1 WP_260709492.1
Microbispora rosea subsp. aerata, TEP061 Norton-Baker et al., 2025GGO06455.1 GGO06455.1
Actinomadura sp. K4S16, TEP067 Norton-Baker et al., 2025WP_149259982.1 WP_149259982.1
Micromonosporaceae bacterium, TEP083 Norton-Baker et al., 2025MBN1171866.1 MBN1171866.1
Cellulomonas iranensis, TEP091 Norton-Baker et al., 2025MBO9569276.1 MBO9569276.1
Plantactinospora endophytica, TEP092 Norton-Baker et al., 2025GIG90696.1 GIG90696.1
Streptomyces swartbergensis, TEP097 Norton-Baker et al., 2025WP_086599340.1 WP_086599340.1
Actinomadura atramentaria, TEP101 Norton-Baker et al., 2025WP_019633337.1 WP_019633337.1
Streptomyces sp. V2, TEP102 Norton-Baker et al., 2025WP_109361459.1 WP_109361459.1
Kutzneria sp. CA-103260, TEP103 Norton-Baker et al., 2025WP_211769896.1 WP_211769896.1
Saccharopolyspora hirsuta, TEP105 Norton-Baker et al., 2025WP_150070118.1 WP_150070118.1
Kibdelosporangium banguiense, TEP109 Norton-Baker et al., 2025MBP2328848.1 MBP2328848.1
Micromonospora carbonacea, TEP111 Norton-Baker et al., 2025WP_260422593.1 WP_260422593.1
Actinoallomurus spadix, TEP114 Norton-Baker et al., 2025WP_252811421.1 WP_252811421.1
Streptomyces sp. TRM70350, TEP163 Norton-Baker et al., 2025WP_218517662.1 WP_218517662.1
Crossiella sp. SN42, TEP164 Norton-Baker et al., 2025WP_256510519.1 WP_256510519.1
Micromonospora sp. HM5-17, TEP165 Norton-Baker et al., 2025WP_233604767.1 WP_233604767.1
Micromonospora lutea, TEP168 Norton-Baker et al., 2025WP_239095870.1 WP_239095870.1
Hamadaea flava, TEP178 Norton-Baker et al., 2025WP_253762837.1 WP_253762837.1
Actinoplanes ianthinogenes, TEP181 Norton-Baker et al., 2025WP_212846608.1 WP_212846608.1
Acidimicrobiales bacterium, TEP189 Norton-Baker et al., 2025GIU85371.1 GIU85371.1
Sphaerisporangium fuscum, TEP194 Norton-Baker et al., 2025WP_250563816.1 WP_250563816.1
Bacillota
Bacillus subtilis 4P3-11, BsEstB EC 3.1.1.1Ribitsch,2011ADH43200.1 ADH43200.1
Bacillus safensis, LipMRD9EC 3.1.1.3Vidal, 2024APJ12152.1 APJ12152.1
Thermoanaerobacter sp. , PHL-7 (PES-H1; PES-H2)EC 3.1.1.74Sonnendecker, 2022; Pfaff, 20227NEI_A/B /7CUV_A, MBO2503201.1
SAY37592.1		7NEI; 7CUVA/7W697NEI_A / 7CUV_A
Compost metagenome, PHL-32 Sonnendecker, 2022SAY37583.1 SAY37583.1
Clostridium botulinum ATCC3502, Cbotu_EstA3 Perz et al., 2015AKZ20828.1 AKZ20828.1
Cryptosporangium aurantiacum, CaPETase Hong, 2023SHM40309.17YM9, 7YMESHM40309.1
Caldibacillus thermoamylovorans, Lip4_120 EC:3.1.1.3Yan, 2024WP_108898452.1 WP_108898452.1
Caldibacillus thermoamylovorans, Est8_89 EC:4.2.99.20Yan, 2024CEE00769.1 CEE00769.1
Caldibacillus thermoamylovorans, Est11_32 Yan, 2024WP_041846030.1 WP_041846030.1
Caldibacillus thermoamylovorans, Est18_23 EC 3.1.1.-Yan, 2024WP_041847557.1 WP_041847557.1
Caldibacillus thermoamylovorans, Ces19_14 EC 3.1.1.1Yan, 2024WP_034767800.1 WP_034767800.1
Caldibacillus thermoamylovorans, Ces39_5 EC 3.1.1.1Yan, 2024WP_108898647.1 WP_108898647.1
Holdemanella biformis, HG-2 Zhou, 2024WP_118011433 WP_118011433
Clostridiales bacterium AM23-16LB, HG-3 Zhou, 2024RGD93181 RGD93181
Heyndrickxia coagulans, HG-4 Zhou, 2024WP_013858543.1 WP_013858543.1
Longicatena, HG-5 Zhou, 2024
TmFae-PETase (likely Enterococcaceae) Mamtimin, 2024
HGMP01 (likely Acutalibacteraceae) Zhang, 2024
Bacteroidota
Aequorivita sp. CIP111184, PET27EC 3.1.1.1Zhang, 2022WP_111881932 WP_111881932
Kaistella (Chryseobacterium) jeonii, PET30EC 3.1.1.1Zhang, 2022WP_0393534277PZJWP_039353427
Chloroflexota
Chloroflexus sp. MS-G, Enzyme 202 Erickson, 2022YNPsite05_CeleraDRAFT_4014107QJM7QJM_A
Chloroflexi bacterium, IS104 Distaso, 2023UNZ81746 UNZ81746
Chloroflexi bacterium, IS124 Distaso, 2023UNZ81748 UNZ81748
Dehalococcoidia bacterium, IS114 Distaso, 2023UNZ81747 UNZ81747
Deinococcata
Deinococcus maricopensis DSM 21211, PET1/DmPETase Danso et al., 2018; Makryniotis et al., 2023E8U721 ADV66860
Thermodesulfobacteriota
Geothermal metagenome, Sis Ercolano, 2024XDS72785.1 XDS72785.1
Metagenome-derived without a phylogenetic affiliation
Metagenome-derived, no obvious affiliation, PET2, lipIAF5-2EC 3.1.1.1Danso, 2018, Nakamura, 2021ACC95208.17ECB and othersACC95208.1
Metagenome-derived. no obvious affiliation, Enzyme 101 Erickson, 2022YNPsite06_CeleraDRAFT_263770
Metagenome-derived. no obvious affiliation, Enzyme 102 Erickson, 2022YNP6_02150
Metagenome-derived. no obvious affiliation, Enzyme 204 Erickson, 2022YNP18_240440
Metagenome-derived. no obvious affiliation, Enzyme 211 Erickson, 2022JzSedJan11_10004914
Metagenome-derived. no obvious affiliation, Enzyme 214 Erickson, 2022YNPsite06_CeleraDRAFT_160970
Metagenome-derived. no obvious affiliation, Enzyme 301 Erickson, 2022YNPsite06_CeleraDRAFT_367810
Metagenome-derived. no obvious affiliation, Enzyme 305 Erickson, 2022GxsBSedJan11_10251181
Metagenome-derived, no obvious affiliation, Enzyme 307 Erickson, 2022JGI20132J14458_10325381
Compost metagenome, PHL-42 Sonnendecker, 2022SAY37584.1 SAY37584.1
Compost metagenome, PHL-52 Sonnendecker, 2022SAY37587.1 SAY37587.1
Compost metagenome, PHL-62 Sonnendecker, 2022SAY37589.1 SAY37589.1
Archaea
Candidatus Bathyarchaeota archaeon, PET46EC 3.1.1.73Perez-Garcia, 2023RLI42440.18B4URLI42440.1
Eukarya
Pseudozyma (Candida) antarctica, lipase B, CalBEC 3.1.1.3Ronkvist, 2009, Carniel, 2017; Brackmann, 2023LIPB_PSEA21TCA and othersLIPB_PSEA2
Pseudozyma (Candida) antarctica, CaLEC 3.1.1.3Brackmann, 2023
Fusarium solani , FsCEC 3.1.1.74Silva, 2005AAA33335.11AGY and othersAAA33335.1
Fusarium oxysporum, FoCut5aEC 3.1.1.74Dimarogona, 2015X0BTD85AJHEXK81749
Humicola insolens , HiCEC 3.1.1.74Ronkvist, 2009, Carniel, 2017; Brackmann, 2023A0A075B5G44OYL and others4OYY_A
Thermomyces lanuginosus, Lipozyme TLEC 3.1.1.3Brueckner, 2008; Eberl, 2009; Brackmann, 2023
Moniliophthora roreri, MRCUT1EC 3.1.1.74Vázquez-Alcántara, 2021ESK97883 ESK97883
Rhizomucor miehei, RmLEC 3.1.1.3Brackmann, 2023
Dactylonectria macrodidyma, DmCEC 3.1.1.74Brinch-Pedersen, 2024KAH7127633 KAH7127633
Thermocarpiscus australiensis, TaCEC 3.1.1.74Brinch-Pedersen, 2024KAL2018089 KAL2018089
Remersonia thermophila, RtCEC 3.1.1.74Brinch-Pedersen, 2024KAL1836386 KAL1836386
Mammal glutathione S-transferase6 Huang, 2024
Homo sapiens, Trypsin Huang, 2024
Homo sapiens, CYP450 Huang, 2024
Nepenthes distillatoria, Nepenthesin-1 Siracusa et al., 2025
Engineered enzymes without WT hydrolase activity
Actinia fragacea, FraC5 Robles-Martín, 2023

1 Now named Piscinibacter sakaiensis.

2 Only weight loss of PET substrate observed.

3 Only marginal concentrations of hydrolysis products released.

4 Only degradation of 3PET shown.

5 Non-catalytic actinoporin membrane pore. Catalytic triad and oxyanion hole were added by protein engineering.

6 Proposed mechanism: cleavage and release of monomers via nitridation and oxidation of PET.

pet.txt · Last modified: 2025/09/24 08:47 by golo1122